What defines Ehlers-Danlos syndrome?

Ehlers-Danlos syndrome is defined as a congenital connective tissue disorder, characterized by a group of conditions that affect the extracellular matrix, leading to symptoms that often manifest as hyper-elastic skin, joint hypermobility, and tissue fragility. This syndrome results from genetic mutations that impact collagen synthesis and structure, which is essential for maintaining the integrity of connective tissues throughout the body. The congenital nature of this disorder means that it is present from birth, often hereditary, and may be identified early in life through clinical signs.

In contrast, the other options highlight different pathologies that do not pertain to Ehlers-Danlos syndrome. Increased blood pressure is a cardiovascular issue that can arise due to various factors but is not associated with the connective tissue properties of Ehlers-Danlos. Acquired metabolic disorders relate to issues with metabolism, which do not describe the genetic connective tissue abnormalities present in Ehlers-Danlos. Lastly, a rare neurological condition would refer to disorders primarily affecting the nervous system rather than the connective tissues. Therefore, identifying Ehlers-Danlos syndrome correctly as a congenital connective tissue disorder underscores its genetic roots and clinical presentation.